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Issue 24, 2014
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The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

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Abstract

The transient formation of nitrilimine in aqueous conditions is greatly influenced by pH and chloride. In basic conditions (pH 10) with no chloride, a diarylnitrilimine precursor readily ionizes to form diarylnitrilimine that reacts almost instantly with an acrylamide-containing protein and fluorescently labels it.

Graphical abstract: The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

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Supplementary files

Article information


Submitted
14 Nov 2013
Accepted
19 Dec 2013
First published
20 Dec 2013

Chem. Commun., 2014,50, 3176-3179
Article type
Communication
Author version available

The nitrilimine–alkene cycloaddition is an ultra rapid click reaction

X. S. Wang, Y. Lee and W. R. Liu, Chem. Commun., 2014, 50, 3176
DOI: 10.1039/C3CC48682F

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