Issue 11, 2014
From the journal:

Chemical Communications

Co-delivery of small interfering RNA using a camptothecin prodrug as the carrier†

Qiong Tang,‡a   Bin Cao‡a  and  Gang Cheng*a  

* Corresponding authors

a Department of Chemical and Biomolecular Engineering, University of Akron, Akron, OH 44325, USA
E-mail: gc@uakron.edu
Fax: +1-330-972-5856
Tel: +1-330-972-8680

Abstract

We have reported the first effort towards directly using an anticancer prodrug (CPTssR5H5) as a carrier to co-deliver camptothecin (CPT) and small interfering RNA for multidrug resistant cancer chemotherapy. The results indicated that CPTssR5H5 is a promising co-delivery system for MDR cancer therapy.

Graphical abstract: Co-delivery of small interfering RNA using a camptothecin prodrug as the carrier

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Article information

DOI
https://doi.org/10.1039/C3CC47970F
Article type
Communication
Submitted
16 Oct 2013
Accepted
21 Nov 2013
First published
17 Dec 2013

Chem. Commun., 2014,50, 1323-1325

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Co-delivery of small interfering RNA using a camptothecin prodrug as the carrier

Q. Tang, B. Cao and G. Cheng, Chem. Commun., 2014, 50, 1323 DOI: 10.1039/C3CC47970F

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