Issue 8, 2014
From the journal:

Chemical Communications

Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex†

Quanjun Wang,a   Xueying Liu,a   Xian Liu,a   Bin Li,a   Huifang Nie,a   Shengyong Zhang*a  and  Weiping Chen*a  

* Corresponding authors

a School of Pharmacy, Fourth Military Medical University, 169 Changle West Road, Xi'an, P.R. China
E-mail: wpchen@fmmu.edu.cn

Abstract

Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos–Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step.

Graphical abstract: Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex

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Article information

DOI
https://doi.org/10.1039/C3CC47727D
Article type
Communication
Submitted
08 Oct 2013
Accepted
13 Nov 2013
First published
13 Nov 2013

Chem. Commun., 2014,50, 978-980

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Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex

Q. Wang, X. Liu, X. Liu, B. Li, H. Nie, S. Zhang and W. Chen, Chem. Commun., 2014, 50, 978 DOI: 10.1039/C3CC47727D

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