Issue 40, 2014

Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer

Abstract

A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.

Graphical abstract: Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2013
Accepted
07 Feb 2014
First published
21 Feb 2014

Chem. Commun., 2014,50, 5345-5348

Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer

M. Kim, M. Gkikas, A. Huang, J. W. Kang, N. Suthiwangcharoen, R. Nagarajan and B. D. Olsen, Chem. Commun., 2014, 50, 5345 DOI: 10.1039/C3CC47675H

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