High yield and high specific activity synthesis of [18F]fallypride in a batch microfluidic reactor for micro-PET imaging

Muhammad Rashed Javed; Supin Chen; Jack Lei; Jeffrey Collins; Maxim Sergeev; Hee-Kwon Kim; Chang-Jin Kim; R. Michael van Dam; Pei Yuin Keng

doi:10.1039/C3CC47616B

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High yield and high specific activity synthesis of [¹⁸F]fallypride in a batch microfluidic reactor for micro-PET imaging†

Muhammad Rashed Javed,^ab Supin Chen,^c Jack Lei,^ab Jeffrey Collins,^b Maxim Sergeev,^ab Hee-Kwon Kim,^ab Chang-Jin Kim,^cd R. Michael van Dam^abc and Pei Yuin Keng*^ab

Author affiliations

* Corresponding authors

^a Department of Molecular Imaging and Medical Pharmacology, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA
E-mail: pkeng@mednet.ucla.edu
Fax: +1 310 206 8975
Tel: +1 310 983 3194

^b Crump Institute for Molecular Imaging, University of California Los Angeles, 570 Westwood Plaza, Los Angeles, USA

^c Bioengineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, USA

^d Mechanical and Aerospace Engineering Department, University of California Los Angeles, 420 Westwood Plaza, Los Angeles, USA

Abstract

[¹⁸F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol⁻¹ (20 Ci μmol⁻¹) (n = 4). Specific activity was ∼2-fold higher than [¹⁸F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

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Article information

DOI: https://doi.org/10.1039/C3CC47616B
Article type: Communication
Submitted: 04 Oct 2013
Accepted: 19 Nov 2013
First published: 20 Nov 2013

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Chem. Commun., 2014,50, 1192-1194

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High yield and high specific activity synthesis of [¹⁸F]fallypride in a batch microfluidic reactor for micro-PET imaging

M. R. Javed, S. Chen, J. Lei, J. Collins, M. Sergeev, H. Kim, C. Kim, R. M. van Dam and P. Y. Keng, Chem. Commun., 2014, 50, 1192 DOI: 10.1039/C3CC47616B

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Chemical Communications