Issue 18, 2014
From the journal:

Chemical Communications

High mitochondrial accumulation of new gadolinium(iii) agents within tumour cells†

Daniel E. Morrison,a   Jade B. Aitken,abc   Martin D. de Jonge,b   Joseph A. Ioppolo,a   Hugh H. Harrisd  and  Louis M. Rendina*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia
E-mail: lou.rendina@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 4781

b Australian Synchrotron, Clayton, Victoria 3168, Australia

c Institute of Materials Structure Science, KEK, Tsukuba, Ibaraki 305-0801, Japan

d School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia

Abstract

The first bifunctional GdIII complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 1010 Gd atoms per tumour cell.

Graphical abstract: High mitochondrial accumulation of new gadolinium(iii) agents within tumour cells

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC46903D
Article type
Communication
Submitted
10 Sep 2013
Accepted
26 Nov 2013
First published
19 Dec 2013

Chem. Commun., 2014,50, 2252-2254

Author version available

Download author version (PDF)

Permissions

Request permissions

High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

D. E. Morrison, J. B. Aitken, M. D. de Jonge, J. A. Ioppolo, H. H. Harris and L. M. Rendina, Chem. Commun., 2014, 50, 2252 DOI: 10.1039/C3CC46903D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements