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Issue 40, 2014
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The cross-selective titanium(iii)-catalysed acyloin reaction

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A titanium(III)-catalysed intermolecular reductive coupling of ketones or imines with nitriles is described, which gives direct access to α-hydroxylated and α-aminated ketones. This coupling reaction is cross-selective and a catalytic version of the classical acyloin condensation. A reaction mechanism that is supported by first DFT calculations is discussed.

Graphical abstract: The cross-selective titanium(iii)-catalysed acyloin reaction

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Article information

09 Sep 2013
02 Oct 2013
First published
03 Oct 2013

Chem. Commun., 2014,50, 5370-5372
Article type

The cross-selective titanium(III)-catalysed acyloin reaction

M. Feurer, G. Frey, H. Luu, D. Kratzert and J. Streuff, Chem. Commun., 2014, 50, 5370
DOI: 10.1039/C3CC46894A

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