The cross-selective titanium(iii)-catalysed acyloin reaction†
A titanium(III)-catalysed intermolecular reductive coupling of ketones or imines with nitriles is described, which gives direct access to α-hydroxylated and α-aminated ketones. This coupling reaction is cross-selective and a catalytic version of the classical acyloin condensation. A reaction mechanism that is supported by first DFT calculations is discussed.
- This article is part of the themed collection: 2014 Emerging Investigators