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Issue 40, 2014
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γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

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Abstract

We report the design, synthesis, characterization and evaluation of a novel class of γ-AApeptide one-bead-one-compound (OBOC) library, from which a small γ-AApeptide was identified to effectively prevent and disassemble Aβ aggregation.

Graphical abstract: γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

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Publication details

The article was received on 01 Sep 2013, accepted on 10 Oct 2013 and first published on 10 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC46685J
Citation: Chem. Commun., 2014,50, 5206-5208

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    γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation

    H. Wu, Y. Li, G. Bai, Y. Niu, Q. Qiao, J. D. Tipton, C. Cao and J. Cai, Chem. Commun., 2014, 50, 5206
    DOI: 10.1039/C3CC46685J

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