Issue 4, 2014
From the journal:

Chemical Communications

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders†

Chiara Cassiano,a   Roberta Esposito,a   Alessandra Tosco,a   Angela Zampella,b   Maria Valeria D'Auria,b   Raffaele Riccio,a   Agostino Casapulloa  and  Maria Chiara Monti*a  

* Corresponding authors

a Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano (Sa), Italy
E-mail: mcmonti@unisa.it
Fax: +39-089-969602
Tel: +39-089-969453

b Department of Pharmacy, University of Napoli, ‘Federico II’ Via Montesanto, Naples, Italy

Abstract

Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization.

Graphical abstract: Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

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Article information

DOI
https://doi.org/10.1039/C3CC45454A
Article type
Communication
Submitted
18 Jul 2013
Accepted
05 Aug 2013
First published
07 Aug 2013

Chem. Commun., 2014,50, 406-408

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Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

C. Cassiano, R. Esposito, A. Tosco, A. Zampella, M. V. D'Auria, R. Riccio, A. Casapullo and M. C. Monti, Chem. Commun., 2014, 50, 406 DOI: 10.1039/C3CC45454A

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