Issue 98, 2013
From the journal:

Chemical Communications

Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen†

Natsuhisa Oka,*a   Yasuhiro Morita,a   Yuta Itakuraa  and  Kaori Andoa  

* Corresponding authors

a Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
E-mail: oka@gifu-u.ac.jp
Fax: +81 58 293 2564
Tel: +81 58 293 2564

Abstract

Inosine derivatives bearing a phosphodiester group at the O6-position of the nucleobase were synthesized via phosphitylation of the carbonyl oxygen using phosphoramidites activated by non-nucleophilic acidic activators.

Graphical abstract: Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

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Article information

DOI
https://doi.org/10.1039/C3CC46617E
Article type
Communication
Submitted
29 Aug 2013
Accepted
16 Oct 2013
First published
17 Oct 2013

Chem. Commun., 2013,49, 11503-11505

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Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

N. Oka, Y. Morita, Y. Itakura and K. Ando, Chem. Commun., 2013, 49, 11503 DOI: 10.1039/C3CC46617E

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