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Issue 88, 2013

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

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Abstract

The anti-HIV nucleoside lamivudine was asymmetrically synthesized in only three steps via a novel surfactant-treated subtilisin Carlsberg-catalyzed dynamic kinetic resolution protocol. The enantiomer of lamivudine could also be accessed using the same protocol catalyzed by Candida antarctica lipase B.

Graphical abstract: Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

Supplementary files

Article information


Submitted
22 Jul 2013
Accepted
09 Sep 2013
First published
10 Sep 2013

This article is Open Access

Chem. Commun., 2013,49, 10376-10378
Article type
Communication

Efficient asymmetric synthesis of lamivudine via enzymatic dynamic kinetic resolution

L. Hu, F. Schaufelberger, Y. Zhang and O. Ramström, Chem. Commun., 2013, 49, 10376 DOI: 10.1039/C3CC45551C

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