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Issue 83, 2013
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Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

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Abstract

We present a primary example of a cell surface modified with a synergistic combination of agonists to tune immune stimulation. A model cell line, Lewis Lung Carcinoma, was covalently modified with CpG-oligonucleotides and lipoteichoic acid, both Toll-like receptor (TLR) agonists. The immune-stimulating constructs provided greater stimulation of NF-κB in a model cell line and bone marrow-derived dendritic cells than the components unconjugated in solution.

Graphical abstract: Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

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Supplementary files

Article information


Submitted
19 Jul 2013
Accepted
26 Aug 2013
First published
27 Aug 2013

Chem. Commun., 2013,49, 9618-9620
Article type
Communication

Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

J. K. Tom, R. J. Mancini and A. P. Esser-Kahn, Chem. Commun., 2013, 49, 9618
DOI: 10.1039/C3CC45468A

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