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Issue 82, 2013
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An ultrasensitive homogeneous chemiluminescent assay for microRNAs

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Abstract

On the basis of a dual-amplification strategy, microRNA (miRNA) hybridization amplification by a duplex-specific nuclease (DSN) and signal amplification by a DNAzyme, a highly sensitive and selective homogeneous miRNA assay is developed. By leveraging on the cumulative and selective nature of the DSN amplification process, excellent sensitivity and selectivity are accomplished.

Graphical abstract: An ultrasensitive homogeneous chemiluminescent assay for microRNAs

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Article information


Submitted
27 Jun 2013
Accepted
13 Aug 2013
First published
09 Sep 2013

Chem. Commun., 2013,49, 9401-9403
Article type
Communication

An ultrasensitive homogeneous chemiluminescent assay for microRNAs

H. Deng, Y. Ren, W. Shen and Z. Gao, Chem. Commun., 2013, 49, 9401
DOI: 10.1039/C3CC44824J

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