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Issue 70, 2013
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Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

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Abstract

An efficient synthesis of racemic or optically active α-amino acids by modified-Mitsunobu alkylation of a racemic or chiral glycine template from alcohols was developed. Libraries of amino acids were prepared in moderate to good yield with good to high enantioselectivity. This simple method widens the scope for preparation of structurally diverse amino acids.

Graphical abstract: Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

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Article information


Submitted
23 Jun 2013
Accepted
10 Jul 2013
First published
12 Jul 2013

Chem. Commun., 2013,49, 7744-7746
Article type
Communication

Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

A. F. M. Noisier, C. S. Harris and M. A. Brimble, Chem. Commun., 2013, 49, 7744
DOI: 10.1039/C3CC44717K

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