Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines

Abdul Karim Haji Dheere; Nadiya Yusuf; Antony Gee

doi:10.1039/C3CC44046J

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Rapid and efficient synthesis of [¹¹C]ureas via the incorporation of [¹¹C]CO₂ into aliphatic and aromatic amines†

Abdul Karim Haji Dheere,^a Nadiya Yusuf^a and Antony Gee*^a

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* Corresponding authors

^a Division of Imaging Sciences and Biomedical Engineering, King's College London, UK
E-mail: antony.gee@kcl.ac.uk
Fax: +44 (0)20 718 85442
Tel: +44 (0)20 718 88366

Abstract

A rapid urea radiolabelling methodology has been developed. [¹¹C]CO₂ was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric ¹¹C radiolabelled ureas in high radiochemical yields.

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Article information

DOI: https://doi.org/10.1039/C3CC44046J
Article type: Communication
Submitted: 29 May 2013
Accepted: 29 Jul 2013
First published: 31 Jul 2013
This article is Open Access

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Chem. Commun., 2013,49, 8193-8195

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Rapid and efficient synthesis of [¹¹C]ureas via the incorporation of [¹¹C]CO₂ into aliphatic and aromatic amines

A. K. Haji Dheere, N. Yusuf and A. Gee, Chem. Commun., 2013, 49, 8193 DOI: 10.1039/C3CC44046J

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Chemical Communications