Issue 78, 2013

Sensitive label-free monitoring of protein kinase activity and inhibition using ferric ions coordinated to phosphorylated sites as electrocatalysts

Abstract

Ferric ions show high affinity to the kinase-generated phosphorylated sites of peptides. Thus, the high electrocatalytic activity of the coordinated ferric ions toward the reduction of hydrogen peroxide can be used for sensitive label-free monitoring of protein kinase activity and inhibition.

Graphical abstract: Sensitive label-free monitoring of protein kinase activity and inhibition using ferric ions coordinated to phosphorylated sites as electrocatalysts

Supplementary files

Article information

Article type
Communication
Submitted
03 May 2013
Accepted
30 Jul 2013
First published
31 Jul 2013

Chem. Commun., 2013,49, 8788-8790

Sensitive label-free monitoring of protein kinase activity and inhibition using ferric ions coordinated to phosphorylated sites as electrocatalysts

M. Wang, G. Wang, F. Xiao, Y. Zhao, K. Wang and X. Xia, Chem. Commun., 2013, 49, 8788 DOI: 10.1039/C3CC43290D

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