Issue 60, 2013
From the journal:

Chemical Communications

Alcohol assisted C–C bond breaking: copper-catalyzed deacetylative α-arylation of β-keto esters and amides†

Jie Ke,‡a   Chuan He,‡a   Huiying Liu,a   Huan Xua  and  Aiwen Lei*ab  

* Corresponding authors

a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: aiwenlei@whu.edu.cn

b State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou, P. R. China

Abstract

A method of alcohol-assisted copper-catalyzed highly selective deacetylative α-arylation of β-keto esters and amides has been demonstrated, which illustrated an efficient example of achieving α-aryl esters and amides. From the synthetic point of view, this arylation protocol is general and practical, representing a simple way to produce α-arylated carbonyl compounds from basic starting materials at low cost.

Graphical abstract: Alcohol assisted C–C bond breaking: copper-catalyzed deacetylative α-arylation of β-keto esters and amides

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Article information

DOI
https://doi.org/10.1039/C3CC43279C
Article type
Communication
Submitted
03 May 2013
Accepted
04 Jun 2013
First published
04 Jun 2013

Chem. Commun., 2013,49, 6767-6769

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Alcohol assisted C–C bond breaking: copper-catalyzed deacetylative α-arylation of β-keto esters and amides

J. Ke, C. He, H. Liu, H. Xu and A. Lei, Chem. Commun., 2013, 49, 6767 DOI: 10.1039/C3CC43279C

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