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Issue 78, 2013
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Allylic C–H alkylation with a CF3-containing nucleophile

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Abstract

Allylic C–H alkylation of allylarenes with dimethyl 2-trifluoromethylmalonate was successfully developed. The reactions were carried out at room temperature in the presence of a catalytic amount of Pd(OAc)2/Ph3P and a stoichiometric amount of 2,6-dimethylbenzoquinone. The reactions avoided defluorination successfully, providing a new method to construct a CF3-containing all-carbon quaternary center.

Graphical abstract: Allylic C–H alkylation with a CF3-containing nucleophile

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Publication details

The article was received on 26 Apr 2013, accepted on 23 Jul 2013 and first published on 23 Jul 2013


Article type: Communication
DOI: 10.1039/C3CC43120G
Citation: Chem. Commun., 2013,49, 8764-8766

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    Allylic C–H alkylation with a CF3-containing nucleophile

    L. Li, Q. Chen and Y. Guo, Chem. Commun., 2013, 49, 8764
    DOI: 10.1039/C3CC43120G

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