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Issue 56, 2013
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AlCl3-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

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Abstract

An unprecedented AlCl3-mediated method has been developed involving aromatic C–H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.

Graphical abstract: AlCl3-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

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Article information


Submitted
17 Apr 2013
Accepted
21 May 2013
First published
22 May 2013

Chem. Commun., 2013,49, 6268-6270
Article type
Communication

AlCl3-mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest

A. Nakhi, S. Archana, G. P. K. Seerapu, K. S. Chennubhotla, K. L. Kumar, P. Kulkarni, D. Haldar and M. Pal, Chem. Commun., 2013, 49, 6268
DOI: 10.1039/C3CC42840K

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