Issue 47, 2013
From the journal:

Chemical Communications

Light-inducible molecular beacons for spatio-temporally highly defined activation†

Jennifer S. Rinne,a   Tim P. Kaminski,b   Ulrich Kubitscheck*b  and  Alexander Heckel*a  

* Corresponding authors

a Goethe University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany
E-mail: heckel@uni-frankfurt.de

b Rheinische Friedrich Wilhelms-Universität Bonn, Institute for Physical and Theoretical Chemistry, Wegelerstr. 12, 53115 Bonn, Germany
E-mail: u.kubitscheck@uni-bonn.de

Abstract

We have developed a new molecular beacon design that requires an additional UV pulse for fluorescence activation. This improves the signal-to-noise ratio tremendously compared to previous approaches and allows for a precise control of the time point and location of RNA labelling.

Graphical abstract: Light-inducible molecular beacons for spatio-temporally highly defined activation

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Article information

DOI
https://doi.org/10.1039/C3CC42420K
Article type
Communication
Submitted
03 Apr 2013
Accepted
23 Apr 2013
First published
24 Apr 2013

Chem. Commun., 2013,49, 5375-5377

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Light-inducible molecular beacons for spatio-temporally highly defined activation

J. S. Rinne, T. P. Kaminski, U. Kubitscheck and A. Heckel, Chem. Commun., 2013, 49, 5375 DOI: 10.1039/C3CC42420K

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