Issue 47, 2013

Palladium-catalyzed cross-coupling of cyclopropanol-derived ketone homoenolates with aryl bromides

Abstract

The cross-coupling reaction of cyclopropanol-derived ketone homoenolates bearing β-hydrogens with aryl and hetaryl bromides has been achieved for the first time. This reaction is high yielding, is broad in scope and uses a simple catalytic system. Notably, the proposed palladium homoenolates do not undergo β-hydride elimination to the corresponding α,β-unsaturated ketones.

Graphical abstract: Palladium-catalyzed cross-coupling of cyclopropanol-derived ketone homoenolates with aryl bromides

Supplementary files

Article information

Article type
Communication
Submitted
21 Mar 2013
Accepted
22 Apr 2013
First published
24 Apr 2013

Chem. Commun., 2013,49, 5420-5422

Palladium-catalyzed cross-coupling of cyclopropanol-derived ketone homoenolates with aryl bromides

D. Rosa and A. Orellana, Chem. Commun., 2013, 49, 5420 DOI: 10.1039/C3CC42080A

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