Issue 52, 2013
From the journal:

Chemical Communications

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor†

Luigi Margarucci,a   Maria Chiara Monti,a   Chiara Cassiano,a   Matteo Mozzicafreddo,b   Mauro Angeletti,b   Raffaele Riccio,a   Alessandra Tosco*a  and  Agostino Casapullo*a  

* Corresponding authors

a Dipartimento di Farmacia, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy
E-mail: casapullo@unisa.it, tosco@unisa.it
Fax: +39 089 96960

b Scuola di Bioscienze e Biotecnologie, Università degli Studi di Camerino, via Gentile III da Varano, 62032 Camerino, Italy

Abstract

Hsp90, a key target in cancer therapy, has been identified as the main partner of oleocanthal, an olive oil bioactive compound. A combination of chemical and biological assays disclosed its mechanism of action at the molecular level.

Graphical abstract: Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

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Article information

DOI
https://doi.org/10.1039/C3CC41858H
Article type
Communication
Submitted
12 Mar 2013
Accepted
09 May 2013
First published
09 May 2013

Chem. Commun., 2013,49, 5844-5846

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Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor

L. Margarucci, M. C. Monti, C. Cassiano, M. Mozzicafreddo, M. Angeletti, R. Riccio, A. Tosco and A. Casapullo, Chem. Commun., 2013, 49, 5844 DOI: 10.1039/C3CC41858H

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