Issue 60, 2013

Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

Abstract

A solid-phase synthesis approach to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) specific for trypsin is described. The protein is immobilized on a solid support upon which thermoresponsive MIP-NPs are synthesized. The MIP-NPs are released by a simple temperature change, resulting in synthetic antibody mimics exhibiting high specificity and selectivity for trypsin.

Graphical abstract: Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2013
Accepted
03 Jun 2013
First published
04 Jun 2013

Chem. Commun., 2013,49, 6746-6748

Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

S. Ambrosini, S. Beyazit, K. Haupt and B. Tse Sum Bui, Chem. Commun., 2013, 49, 6746 DOI: 10.1039/C3CC41701H

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