Issue 52, 2013
From the journal:

Chemical Communications

Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions†

Artur R. Stefankiewicz*a  and  Jeremy K. M. Sanders*a  

* Corresponding authors

a University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: as2044@cam.ac.uk, jkms@cam.ac.uk
Fax: +44 (0)122333617

Abstract

We describe here the use of disulfide exchange reactions to generate distinct supramolecular topologies within a dynamic combinatorial library (DCL) derived from tri- and mono-functionalised thiol components in water. This approach allows for the effective expansion of structural diversity within a DCL, and also provides a sensitive probe for weak supramolecular interactions.

Graphical abstract: Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions

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Article information

DOI
https://doi.org/10.1039/C3CC41158C
Article type
Communication
Submitted
12 Feb 2013
Accepted
05 Mar 2013
First published
14 Mar 2013

Chem. Commun., 2013,49, 5820-5822

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Diverse topologies in dynamic combinatorial libraries from tri- and mono-thiols in water: sensitivity to weak supramolecular interactions

A. R. Stefankiewicz and J. K. M. Sanders, Chem. Commun., 2013, 49, 5820 DOI: 10.1039/C3CC41158C

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