Issue 42, 2013
From the journal:

Chemical Communications

Bis[zinc(ii)dipicolylamino]-functionalised peptides as high affinity receptors for pyrophosphate ions in water†

Karen K. Y. Yuena  and  Katrina A. Jolliffe*a  

* Corresponding authors

a School of Chemistry, The University of Sydney, 2006, NSW, Australia
E-mail: kate.jolliffe@sydney.edu.au
Fax: +61 2 9351 3329
Tel: +61 2 9351 2297

Abstract

A library of bis[zinc(II)dipicolylamine]-functionalised linear peptides was prepared using an efficient solid phase peptide synthesis approach and their use as chemosensors for anions in water was investigated using indicator displacement assays. High affinity and selectivity for pyrophosphate (PPi) over adenosine triphosphate (ATP) and adenosine diphosphate (ADP) were observed and additional aromatic side chains provided enhanced discrimination between PPi and ATP.

Graphical abstract: Bis[zinc(ii)dipicolylamino]-functionalised peptides as high affinity receptors for pyrophosphate ions in water

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Article information

DOI
https://doi.org/10.1039/C3CC40937F
Article type
Communication
Submitted
04 Feb 2013
Accepted
05 Apr 2013
First published
08 Apr 2013
This article is Open Access
Creative Commons BY license

Chem. Commun., 2013,49, 4824-4826

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Bis[zinc(II)dipicolylamino]-functionalised peptides as high affinity receptors for pyrophosphate ions in water

K. K. Y. Yuen and K. A. Jolliffe, Chem. Commun., 2013, 49, 4824 DOI: 10.1039/C3CC40937F

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