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Issue 49, 2013
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Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase

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Abstract

N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC50 value of 1.0 μM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH–lactate dehydrogenase (LDH) is also reported.

Graphical abstract: Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase

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Article information


Submitted
29 Jan 2013
Accepted
27 Feb 2013
First published
28 Feb 2013

Chem. Commun., 2013,49, 5535-5537
Article type
Communication

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase

D. Hayashi, N. Kato, T. Kuzuyama, Y. Sato and J. Ohkanda, Chem. Commun., 2013, 49, 5535
DOI: 10.1039/C3CC40758F

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