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Issue 28, 2013
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Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: a simple approach to enaminone synthesis

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Abstract

An efficient method for the synthesis of enaminones is described. The aldol-type addition of ketones to aromatic nitriles proceeded smoothly in the presence of a simple copper catalyst system (CuI–2,2′-bipyridine–NaOtBu) in N,N-dimethylformamide. Enaminones in satisfactory to excellent yields were produced using this technique.

Graphical abstract: Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: a simple approach to enaminone synthesis

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Article information


Submitted
19 Jan 2013
Accepted
19 Feb 2013
First published
19 Feb 2013

Chem. Commun., 2013,49, 2885-2887
Article type
Communication

Copper-catalyzed aldol-type addition of ketones to aromatic nitriles: a simple approach to enaminone synthesis

X. Yu, L. Wang, X. Feng, M. Bao and Y. Yamamoto, Chem. Commun., 2013, 49, 2885
DOI: 10.1039/C3CC40466H

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