In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles

Jessica Morlieras; Jean-Michel Chezal; Elizabeth Miot-Noirault; Aurélien Vidal; Sophie Besse; David Kryza; Charles Truillet; Anna Mignot; Rodolphe Antoine; Philippe Dugourd; Françoise Redini; Lucie Sancey; François Lux; Pascal Perriat; Marc Janier; Olivier Tillement

doi:10.1039/C3CC39106J

In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles†

Jessica Morlieras,^a Jean-Michel Chezal,^bcd Elizabeth Miot-Noirault,^bcd Aurélien Vidal,^bcd Sophie Besse,^bcd David Kryza,^ae Charles Truillet,^a Anna Mignot,^afg Rodolphe Antoine,^h Philippe Dugourd,^h Françoise Redini,ⁱ Lucie Sancey,^a François Lux,*^a Pascal Perriat,^a Marc Janier^ae and Olivier Tillement^a

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* Corresponding authors

^a Laboratoire de Physico-Chimie des Matériaux Luminescents, UMR 5620 CNRS – Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne Cedex, France
E-mail: francois.lux@univ-lyon1.fr
Tel: +33 472431200

^b INSERM UMR 990 – BP 184, Clermont-Ferrand, 63005 Cedex, France

^c Clermont Université, UMR 990 – Université d'Auvergne, BP 10448, 63000 Clermont-Ferrand, France

^d Centre Jean Perrin, 63011 Clermont-Ferrand, France

^e Hôpitaux de Lyon, Hôpital Edouard Herriot, Laboratoire de Biochimie et Biologie moléculaire et Service de médecine nucléaire, 69437 Lyon, France

^f Matériaux, Ingénierie et Sciences, INSA Lyon, UMR 5510 CNRS – Université de Lyon, 69621 Villeurbanne Cedex, France

^g Nano-H SAS, 38070 Saint-Quentin Fallavier, France

^h Laboratoire de Spectrométrie Ionique et Moléculaire, UMR 5579 CNRS – Université Claude Bernard Lyon 1, 69622 Villeurbanne Cedex, France

ⁱ UMR S 957 INSERM/Nantes, Atlantique Universite, 44000 Nantes cedex, France

Abstract

Ultrasmall gadolinium based particles have been functionalized with positively charged pyridinium quaternary ammonium and labelled with ¹¹¹In. Evidence of their active targeting properties towards proteoglycans has been demonstrated in vivo after intravenous injection into rats opening thus a route to cancer imaging and therapy.

Chemical Communications

In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles†

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In vivo evidence of the targeting of cartilaginous tissue by pyridinium functionalized nanoparticles

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