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Issue 20, 2013
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Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

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Abstract

We report the first organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position. Importantly, 3-thiooxindoles and 3-alkoxyoxindoles are demonstrated to be reactive nucleophiles for the development of catalytic asymmetric reactions for the first time.

Graphical abstract: Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

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Article information


Submitted
09 Dec 2012
Accepted
19 Jan 2013
First published
23 Jan 2013

Chem. Commun., 2013,49, 2022-2024
Article type
Communication

Organocatalytic asymmetric synthesis of 3,3-disubstituted oxindoles featuring two heteroatoms at the C3 position

F. Zhou, X. Zeng, C. Wang, X. Zhao and J. Zhou, Chem. Commun., 2013, 49, 2022
DOI: 10.1039/C3CC38819K

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