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Issue 13, 2013
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A two-photonfluorescent probe for amyloid-β plaques in living mice

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Abstract

We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.

Graphical abstract: A two-photon fluorescent probe for amyloid-β plaques in living mice

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Supplementary files

Article information


Submitted
29 Nov 2012
Accepted
19 Dec 2012
First published
20 Dec 2012

Chem. Commun., 2013,49, 1303-1305
Article type
Communication

A two-photon fluorescent probe for amyloid-β plaques in living mice

C. H. Heo, K. H. Kim, H. J. Kim, S. H. Baik, H. Song, Y. S. Kim, J. Lee, I. Mook-jung and H. M. Kim, Chem. Commun., 2013, 49, 1303
DOI: 10.1039/C2CC38570H

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