Issue 15, 2013
From the journal:

Chemical Communications

Mesoporous silicananoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker†

Junseok Lee,a   Juhee Park,a   Kaushik Singhaa  and  Won Jong Kim*a  

* Corresponding authors

a Department of Chemistry, Center for Self-assembly and Complexity, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea
E-mail: wjkim@postech.ac.kr
Fax: +82-54-279-3399
Tel: +82-54-279-2104

Abstract

A photoresponsive drug releasing system based on mesoporous silica nanoparticles (MSN) was developed. A model drug was decorated on the surfaces via singlet oxygen sensitive linkers and a singlet oxygen-generating photosensitizer was loaded in the mesopores of the MSN. An on-demand drug releasing system was successfully developed by irradiation with long-wavelength light.

Graphical abstract: Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker

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Article information

DOI
https://doi.org/10.1039/C2CC38510D
Article type
Communication
Submitted
27 Nov 2012
Accepted
21 Dec 2012
First published
21 Dec 2012

Chem. Commun., 2013,49, 1545-1547

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Mesoporous silica nanoparticle facilitated drug release through cascade photosensitizer activation and cleavage of singlet oxygen sensitive linker

J. Lee, J. Park, K. Singha and W. J. Kim, Chem. Commun., 2013, 49, 1545 DOI: 10.1039/C2CC38510D

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