Issue 12, 2013
From the journal:

Chemical Communications

Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity†

Bruno Alies,ab   Isabelle Sasaki,ab   Olivier Proux,c   Stéphanie Sayen,d   Emmanuel Guillon,d   Peter Faller*ab  and  Christelle Hureau*ab  

* Corresponding authors

a CNRS, LCC (Laboratoire de Chimie de Coordination), 205, route de Narbonne, F-31077 Toulouse, France

b Université de Toulouse, UPS, INPT, LCC, F-31077 Toulouse, France
E-mail: christelle.hureau@lcc-toulouse.fr, peter.faller@lcc-toulouse.fr.
Tel: +33 5 61 33 31 62

c Observatoire des Sciences de l'Univers de Grenoble, CNRS and Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France

d Institut de Chimie Moléculaire de Reims (ICMR, CNRS UMR 7312), Groupe de Chimie de Coordination, Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France

Abstract

Combined coordination of ZnII and CuI or CuII to the amyloid-β peptide has been investigated using XANES, EPR and NMR spectroscopies. While ZnII does alter CuII binding to Aβ, this has no effect on (Aβ)Cu induced ROS production and associated cell toxicity.

Graphical abstract: Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

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Article information

DOI
https://doi.org/10.1039/C2CC38236A
Article type
Communication
Submitted
15 Nov 2012
Accepted
12 Dec 2012
First published
03 Jan 2013

Chem. Commun., 2013,49, 1214-1216

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Zn impacts Cu coordination to amyloid-β, the Alzheimer's peptide, but not the ROS production and the associated cell toxicity

B. Alies, I. Sasaki, O. Proux, S. Sayen, E. Guillon, P. Faller and C. Hureau, Chem. Commun., 2013, 49, 1214 DOI: 10.1039/C2CC38236A

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