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Issue 13, 2013
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Femtomolar Zn(ii) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

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Abstract

The minimal zinc hook peptide of Rad50 and its alanine mutants form highly stable Zn(II) complexes. These peptides were successfully used as a small, efficient tag for reversible Zn(II)-mediated protein homodimerization. The high stability, its biological consequences and potential applications in protein engineering are discussed.

Graphical abstract: Femtomolar Zn(ii) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

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Article information


Submitted
13 Nov 2012
Accepted
20 Dec 2012
First published
21 Dec 2012

Chem. Commun., 2013,49, 1312-1314
Article type
Communication

Femtomolar Zn(II) affinity of minimal zinc hook peptides – a promising small tag for protein engineering

T. Kochańczyk, P. Jakimowicz and A. Krężel, Chem. Commun., 2013, 49, 1312
DOI: 10.1039/C2CC38174E

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