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Issue 12, 2013
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DNA nanostructure serum stability: greater than the sum of its parts

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Abstract

Simple chemical modifications to oligonucleotide ends with hexaethylene glycol and hexanediol are shown to significantly increase nuclease resistance under serum conditions. The modified oligonucleotides were used to construct DNA prismatic cages in a single step and in quantitative yield. These cages further stabilize their strands towards nucleases, with lifetimes of 62 hours in serum. The cages contain a large number of single-stranded regions for functionalization, illustrating their versatility for biological applications.

Graphical abstract: DNA nanostructure serum stability: greater than the sum of its parts

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Article information


Submitted
17 Oct 2012
Accepted
12 Dec 2012
First published
19 Dec 2012

Chem. Commun., 2013,49, 1172-1174
Article type
Communication

DNA nanostructure serum stability: greater than the sum of its parts

J. W. Conway, C. K. McLaughlin, K. J. Castor and H. Sleiman, Chem. Commun., 2013, 49, 1172
DOI: 10.1039/C2CC37556G

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