Issue 2, 2013
From the journal:

Chemical Communications

Bioinspired, releasable quorum sensing modulators†

José Gomes,a   Alexander Grunau,b   Adrien K. Lawrence,c   Leo Eberl*b  and  Karl Gademann*ac  

* Corresponding authors

a Department of Chemistry, NCCR Chemical Biology, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland
E-mail: karl.gademann@unibas.ch

b Department of Microbiology, Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland

c Chemical Synthesis Laboratory, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland

Abstract

We demonstrate the synthesis and immobilization of natural product hybrids featuring an acyl-homoserine lactone and a nitrodopamine onto biocompatible TiO2 surfaces through an operationally simple dip-and-rinse procedure. The resulting immobilized hybrids were shown to be powerful quorum sensing (QS) activators in Pseudomonas strains acting by slow release from the surface.

Graphical abstract: Bioinspired, releasable quorum sensing modulators

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Article information

DOI
https://doi.org/10.1039/C2CC37287H
Article type
Communication
Submitted
05 Oct 2012
Accepted
02 Nov 2012
First published
02 Nov 2012

Chem. Commun., 2013,49, 155-157

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Bioinspired, releasable quorum sensing modulators

J. Gomes, A. Grunau, A. K. Lawrence, L. Eberl and K. Gademann, Chem. Commun., 2013, 49, 155 DOI: 10.1039/C2CC37287H

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