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Issue 39, 2013
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Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

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Abstract

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

Graphical abstract: Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

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Supplementary files

Article information


Submitted
02 Oct 2012
Accepted
25 Oct 2012
First published
16 Nov 2012

Chem. Commun., 2013,49, 4190-4192
Article type
Communication

Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

H. T. T. Duong, Z. M. Kamarudin, R. B. Erlich, Y. Li, M. W. Jones, M. Kavallaris, C. Boyer and T. P. Davis, Chem. Commun., 2013, 49, 4190
DOI: 10.1039/C2CC37181B

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