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Issue 39, 2013
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“Isothermal” LCST transitions triggered by bioreduction of single polymer end-groups

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Abstract

The α-termini of RAFT-derived thermoresponsive polymers were functionalised via thiol exchange with pyridyl disulfide. Addition of hydrophilic end-groups dramatically increased the observed cloud point of the polymers, without changing the composition of the main chain. Selective cleavage of the disulfide-linked end-groups was observed under conditions intended to mimic intracellular glutathione concentration. This allowed the thermoresponsive behaviour to be ‘switched on’ without the need for a temperature stimulus – an ‘isothermal’ switch.

Graphical abstract: “Isothermal” LCST transitions triggered by bioreduction of single polymer end-groups

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Article information


Submitted
13 Jun 2012
Accepted
25 Jun 2012
First published
06 Jul 2012

Chem. Commun., 2013,49, 4223-4225
Article type
Communication

“Isothermal” LCST transitions triggered by bioreduction of single polymer end-groups

M. J. Summers, D. J. Phillips and M. I. Gibson, Chem. Commun., 2013, 49, 4223
DOI: 10.1039/C2CC34236G

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