Issue 80, 2012

Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

Abstract

The analysis of DNA methylation and MTase (methyltransferase) activity is important in epigenetic study. We have developed a novel strategy for sensitive analysis of MTase activity based on a hairpin shaped DNAzyme; 8–17 DNAzyme amplicon has been adopted and found to be very effective in such analysis.

Graphical abstract: Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

Supplementary files

Article information

Article type
Communication
Submitted
14 Jul 2012
Accepted
22 Aug 2012
First published
23 Aug 2012

Chem. Commun., 2012,48, 10031-10033

Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme

T. Tian, H. Xiao, Y. Long, X. Zhang, S. Wang, X. Zhou, S. Liu and X. Zhou, Chem. Commun., 2012, 48, 10031 DOI: 10.1039/C2CC35648A

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