Issue 78, 2012
From the journal:

Chemical Communications

Chemoenzymatic preparation of germacrene analogues†

Oscar Cascón,a   Sabrina Touchet,a   David J. Miller,a   Veronica Gonzalez,a   Juan A. Faraldosa  and  Rudolf K. Allemann*a  

* Corresponding authors

a School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK
E-mail: allemannrk@cardiff.ac.uk
Fax: +44 (0)29 208 74030
Tel: +44 (0)29 208 79014

Abstract

A small library of novel germacrenes was generated using a combination of two plant enzymes, germacrene A synthase, and D synthase and modified farnesyl diphosphate (FDP) analogues. This chemoenzymatic approach allows the preparation of potentially valuable volatiles for biological studies.

Graphical abstract: Chemoenzymatic preparation of germacrene analogues

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Article information

DOI
https://doi.org/10.1039/C2CC35542F
Article type
Communication
Submitted
31 Jul 2012
Accepted
14 Aug 2012
First published
15 Aug 2012
This article is Open Access
Creative Commons BY license

Chem. Commun., 2012,48, 9702-9704

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Chemoenzymatic preparation of germacrene analogues

O. Cascón, S. Touchet, D. J. Miller, V. Gonzalez, J. A. Faraldos and R. K. Allemann, Chem. Commun., 2012, 48, 9702 DOI: 10.1039/C2CC35542F

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