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Issue 83, 2012
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Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

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Abstract

Here, we report 5-hydroxy-1,2,3,4,4a,9a-hexahydro-1,4-ethano-9,10-anthraquinone (13), a small molecule generating reactive oxygen species (ROS) in pH 7.4 buffer under ambient aerobic conditions that has selective and potent Mycobacterium tuberculosis growth inhibitory activity.

Graphical abstract: Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

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Article information


Submitted
24 Jul 2012
Accepted
20 Aug 2012
First published
21 Aug 2012

Chem. Commun., 2012,48, 10325-10327
Article type
Communication

Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

A. T. Dharmaraja, M. Alvala, D. Sriram, P. Yogeeswari and H. Chakrapani, Chem. Commun., 2012, 48, 10325
DOI: 10.1039/C2CC35343A

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