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Issue 71, 2012
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Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

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Abstract

The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst.

Graphical abstract: Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

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Article information


Submitted
09 Jul 2012
Accepted
13 Jul 2012
First published
13 Jul 2012

Chem. Commun., 2012,48, 8892-8894
Article type
Communication

Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocycles

S. Hsieh, M. Binanzer, I. Kreituss and J. W. Bode, Chem. Commun., 2012, 48, 8892
DOI: 10.1039/C2CC34907H

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