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Issue 75, 2012
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Phosphatase reactivity of a dicopper(ii) complex of a patellamide derivative – possible biological functions of cyclic pseudopeptides

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Abstract

A possible biological function of cyclic pseudo-octapeptides is presented. The dinuclear copper(II) complex of a synthetic analogue ([Cu2(H2Pat1)(μ-OH)(OH2)2]) of the naturally occurring ascidiacyclamide is known to have a hydroxo-bridged dicopper(II) site which is able to catalytically transform CO2 into CO32−. This complex is shown here to function as a phosphatase mimic, suggesting that the so far unknown biological function of these macrocycles within the ascidians may involve phosphoester hydrolysis.

Graphical abstract: Phosphatase reactivity of a dicopper(ii) complex of a patellamide derivative – possible biological functions of cyclic pseudopeptides

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Supplementary files

Article information


Submitted
06 Jul 2012
Accepted
27 Jul 2012
First published
27 Jul 2012

Chem. Commun., 2012,48, 9364-9366
Article type
Communication

Phosphatase reactivity of a dicopper(II) complex of a patellamide derivative – possible biological functions of cyclic pseudopeptides

P. Comba, L. R. Gahan, G. R. Hanson and M. Westphal, Chem. Commun., 2012, 48, 9364
DOI: 10.1039/C2CC34836E

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