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Issue 80, 2012
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Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

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Abstract

The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.

Graphical abstract: Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

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Article information


Submitted
30 Jun 2012
Accepted
17 Aug 2012
First published
22 Aug 2012

Chem. Commun., 2012,48, 10013-10015
Article type
Communication

Rational engineering of Candida antarctica lipase B for selective monoacylation of diols

A. Hamberg, S. Maurer and K. Hult, Chem. Commun., 2012, 48, 10013
DOI: 10.1039/C2CC34684B

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