Issue 73, 2012

Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

Abstract

A diamine-catalyzed asymmetric tandem reaction between α,β-unsaturated ketones and rhodanine derivatives has been developed to synthesize various spirocyclic compounds with high stereoselectivities (up to 99% ee and >20 : 1 dr). The products obtained contain two pharmaceutically relevant features: the biologically active rhodanine moiety embedded in a spirocyclic unit.

Graphical abstract: Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2012
Accepted
23 Jul 2012
First published
06 Aug 2012

Chem. Commun., 2012,48, 9180-9182

Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine

W. Wu, H. Huang, X. Yuan, K. Zhu and J. Ye, Chem. Commun., 2012, 48, 9180 DOI: 10.1039/C2CC34321E

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