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Issue 75, 2012
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Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

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Abstract

Non-protected halohydrins are cross-coupled with aryl aluminium reagents to produce aryl alkanols in the presence of the iron–bisphosphine catalysts. Remarkable reaction rate enhancement and diastereoinduction are realized by the in situ generated aluminium alkoxides, offering a new method for the reactivity and selectivity control of the iron-catalysed cross-coupling reaction.

Graphical abstract: Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

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Article information


Submitted
11 Jun 2012
Accepted
23 Jul 2012
First published
24 Jul 2012

Chem. Commun., 2012,48, 9376-9378
Article type
Communication

Iron-catalysed cross-coupling of halohydrins with aryl aluminium reagents: a protecting-group-free strategy attaining remarkable rate enhancement and diastereoinduction

S. Kawamura, T. Kawabata, K. Ishizuka and M. Nakamura, Chem. Commun., 2012, 48, 9376
DOI: 10.1039/C2CC34185A

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