Issue 86, 2012

An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

Abstract

Phosphorylation is an abundant post-translational modification involved in a myriad of cell signaling pathways. Herein, we have engineered the class II lantipeptide synthetase ProcM to generate a variety of peptides containing O-phosphoserine (pSer) and O-phosphothreonine (pThr) residues, either in vitro or in vivo.

Graphical abstract: An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

Supplementary files

Article information

Article type
Communication
Submitted
08 Jun 2012
Accepted
11 Sep 2012
First published
21 Sep 2012
This article is Open Access

Chem. Commun., 2012,48, 10615-10617

An engineered lantipeptide synthetase serves as a general leader peptide-dependent kinase

G. N. Thibodeaux and W. A. van der Donk, Chem. Commun., 2012, 48, 10615 DOI: 10.1039/C2CC34138G

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