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Issue 63, 2012

Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

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Abstract

We describe herein an electrochemically driven drug metabolism strategy based on nanocomposites that integrate cyt P450 2C9 (CYP2C9) isozyme microsomes with cyt P450 reductase (CPR), indium tin oxide (ITO) nanoparticles and chitosan (CS). This novel bioelectronic system enables monitoring of the drug metabolism and enzyme inhibition.

Graphical abstract: Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

Supplementary files

Article information


Submitted
17 May 2012
Accepted
09 Jun 2012
First published
13 Jun 2012

Chem. Commun., 2012,48, 7802-7804
Article type
Communication

Electrochemically driven drug metabolism via cytochrome P450 2C9 isozyme microsomes with cytochrome P450 reductase and indium tin oxide nanoparticle composites

X. Xu, W. Wei, M. Huang, L. Yao and S. Liu, Chem. Commun., 2012, 48, 7802 DOI: 10.1039/C2CC33575A

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