Issue 67, 2012

Surface-modified protein nanospheres as potential antiviral agents

Abstract

A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

Graphical abstract: Surface-modified protein nanospheres as potential antiviral agents

Supplementary files

Article information

Article type
Communication
Submitted
13 May 2012
Accepted
27 Jun 2012
First published
27 Jun 2012

Chem. Commun., 2012,48, 8359-8361

Surface-modified protein nanospheres as potential antiviral agents

D. Baram-Pinto, S. Shukla, M. Richman, A. Gedanken, S. Rahimipour and R. Sarid, Chem. Commun., 2012, 48, 8359 DOI: 10.1039/C2CC33448H

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