Issue 62, 2012
From the journal:

Chemical Communications

Immobilization of engineered arginase on gold-carbon nanotubes†

Gordon Kuen-Chan Lee,a   Sui-Yi Kwok,b   Chih Hao Yu,a   Kin Tam,a   Hiu-Chi Chong,b   Yun-Chung Leungb  and  Shik Chi Edman Tsang*a  

* Corresponding authors

a Department of Chemistry, University of Oxford, Oxford, UK
E-mail: Edman.Tsang@chem.ox.ac.uk

b Department of Applied Biology and Chemical Technology and Lo Ka Chung Center for Natural Anti-Cancer Drug Development, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China

Abstract

It is demonstrated that engineered arginase with a single protruded site of cysteine deliberately placed away from its active centre by site-directed mutagenesis can facilitate its attachment on a gold-nanoparticle surface with atomic precision, resulting in no apparent loss in enzymatic activity.

Graphical abstract: Immobilization of engineered arginase on gold-carbon nanotubes

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Article information

DOI
https://doi.org/10.1039/C2CC32863A
Article type
Communication
Submitted
22 Apr 2012
Accepted
11 Jun 2012
First published
02 Jul 2012

Chem. Commun., 2012,48, 7693-7695

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Immobilization of engineered arginase on gold-carbon nanotubes

G. K. Lee, S. Kwok, C. H. Yu, K. Tam, H. Chong, Y. Leung and S. C. E. Tsang, Chem. Commun., 2012, 48, 7693 DOI: 10.1039/C2CC32863A

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