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Issue 56, 2012
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Copper(ii) mediated facile and ultra fast peptide synthesis in methanol

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Abstract

A novel, ultrafast, mild and scalable amide bond formation strategy in methanol using simple thioacids and amines is described. The mechanism suggests that the coupling reactions are initially mediated by CuSO4·5H2O and subsequently catalyzed by in situ generated copper sulfide. The pure peptides were isolated in satisfactory yields in less than 5 minutes.

Graphical abstract: Copper(ii) mediated facile and ultra fast peptide synthesis in methanol

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Supplementary files

Article information


Submitted
11 Apr 2012
Accepted
24 May 2012
First published
24 May 2012

Chem. Commun., 2012,48, 7085-7087
Article type
Communication

Copper(II) mediated facile and ultra fast peptide synthesis in methanol

S. M. Mali, S. V. Jadhav and H. N. Gopi, Chem. Commun., 2012, 48, 7085
DOI: 10.1039/C2CC32581K

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